A Critical Analysis of the Role of Serotonin in Suicide.

A serotonergic dysfunction in the brain has been reported to be involved in suicidal behaviour independently of the spatial relation of a specific psychiatric disorder (Mann et al., 1999). The seretonergic sensory receptor clay is comprised of fourteen receptor subtypes that ar subdivided into seven families (Raymond et al., 2001). The majority of studies dab cerebrateed on serotonin receptor subtypes, and commence suggested that any(prenominal) of the receptors whitethorn be especially involved in the pathogenesis of depression, suicidal behaviour, aggression and impulsivity. The starting part of this essay depart focus on the situation of serotonin, 5-hydroxytryptamine monoamine neurotransmission (5-HT) in suicide. More specifically, it will look on the studies of the cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) which is the wizard metabolite of 5-HT in depression. The certify part of the essay will check the serotonin receptor abnormal ities. It will look at post-mortem receptor-binding studies that indicated abnormalities in the ventral anterior cortex of patients who committed suicide. Neurochemical abnormalities The 5-HT has a signalize role in the behaviour of humans and other species, much(prenominal) as impulsivity and aggression.

This is due to the 5-HT systems characteristics; they are the signal mediator for the effects of serotonin which is a tidy functional distributor of biliousness sensitivity. Many studies of suicide attempters have confirmed abnormalities in 5-HT neurotransmission and the gamble of suicide has been strongly tally with the belittled co! ncentration of this neurotransmitter. This may be caused by dearths in the uptake of serotonin (Stoff & Mann, 1997). Alterations in neurotransmitter and neuromodulato receptor density could assemble an important role in the neurobiological basis of suicide (Bland, 1997). One of the possible causes of low concentration of CSF 5-HIAA can be explained by a deficit in platelet markers (Asberg & Forslund, 2000). However, the link...If you wish to get a estimable essay, order it on our website: OrderCustomPaper.com

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